Despite the evident advantages of these genetically modified foods, they are insufficiently characterized regarding the impact on human health due to the lack of long term longitudinal studies and studies on the possible interaction between the transferred genetic material from plants and the host genome and transcriptome.
For a long time it was considered that DNA and RNA from food could not resist the protection mechanisms urine test for prostate cancer uk the body and they were degraded during digestion. In this respect, a special attention was paid to microRNAs due to their regulatory action on gene expression.
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The proposed project aims to analyze in a qualitative and quantitative manner the microRNAs transfer from genetically modified and non modified types of soy and corn to mammals mice and its possible effect on the host gene expression patterns in various target tissues.
The project uses a murine model including males, females and pregnant urine test for prostate cancer uk.
In order to achieve the goals of the proposed project, a consortium was set up comprising a University of Agricultural and Food Science, a Medical University and a private company with strong research focuses on food sciences. A multidisciplinary team of researchers was constituted as part of the consortium structure, including specialists in the field of genetically modified organisms and food biosafety, experts in biochemistry, molecular biology and molecular embryology specialized in the analysis of biomarkers of gene expression, together with specialists in the field of food traceability and impact on the consumer.
Apart from the scientific contribution regarding the transfer of genetic material from plant to mammals through food, the proposed project also aims to develop a methodology for selecting and evaluating the impact of plant microRNAs that can be transferred to the consumer, by comparatively analyzing genetically modified and native unmodified plants. The transfer of research results from practice to the private partner consists in the design of a patentable biomarker panel of microRNAs that could be used in biosafety expertise and the possible impact of plant based foodstuffs on the consumer.
Consequently, based on food plant microRNAs expression profile and their possible effect on the consumer organism, one could evaluate the presence of these plants or byproducts in food, and perform a comparative evaluation at target the gene expression level between the impact of a genetically modified plant and its non-genetically modified correspondent.